Binding efficiency and transport properties of molecularly imprinted polymer thin films

作者：Duffy DJ; Das K; Hsu SL^*; Penelle J; Rotello VM; Stidham HD

来源：Journal of the American Chemical Society, 2002, 124(28): 8290-8296.

DOI：10.1021/ja0201146

A model system for the characterization of molecular recognition events in molecularly imprinted polymers (MIPs) is presented. The use of a biologically inspired, three-point hydrogen-bonding motif and a thin film polymeric matrix allows for pre- and post-polymerization binding properties to be characterized by infrared spectroscopy. A method to determine binding constants was developed and utilized before and after cross-linking. These values showed a 10-fold decrease in binding after polymerization, which was attributed to an increase in Molecular confinement after polymerization and a change in the local structural environment of the binding cavity. Transport of the guest molecule was shown to be reversible.

• 出版日期2002-7-17