Associations between polymorphisms in the NR1D1 gene encoding for nuclear receptor REV-ERB alpha and circadian typologies

作者：Kang Jee In; Park Chun Il; Namkoong Kee; Kim Se Joo^*

来源：Chronobiology International, 2015, 32(4): 568-572.

DOI：10.3109/07420528.2015.1006327

• Association
• circadian rhythm
• chronotype
• genetics
• NR1D1 gene
• REV-ERB alpha

Nuclear receptor REV-ERB alpha, a key component of an internal timekeeping system, has been considered to be related to disrupted circadian rhythms and mood disorder. In this study, we aimed to evaluate the relationship between the genotype frequencies of single gene polymorphisms (SNPs) of the NR1D1 gene encoding REV-ERB alpha and circadian typologies. The classification of chronotypes and genotyping of three SNPs (rs2314339, rs2071427, rs12941497) of the NR1D1 gene were conducted in 602 healthy young adults (355 males, 247 females). A significant association was found between the genotypes of rs12941497 and three chronotype categories. These findings support the role of NR1D1 polymorphisms in the regulation of circadian rhythms.

• 出版日期2015-5