An efficient synthesis of 4,6-dihydrospiro[azepino[4,3,2-cd]indole-3,3 '-indoline]-2 ',5(1H)-diones via multi-component reaction

作者：Zou Bin^*; Chen Chun; Leong Seh Yong; Ding Mei; Smith Paul W

来源：Tetrahedron, 2014, 70(3): 578-582.

DOI：10.1016/j.tet.2013.12.010

• Spiroazepinoindolone/spirooxindole
• Isatin
• Indolamine
• Meldrum's acid
• Multi-component reaction

A facile and efficient one-pot three-component synthesis of spiroazepinoindolones has been developed. Using DMF as solvent without any additional acid or metal catalysts, the three-component reaction of readily available isatins, indolamines, and Meldrum's acid affords a new class of spiroheterocycles in moderate yield.

• 出版日期2014-1-21