科研之友
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摘要
We report a short and convenient synthesis of two configurationally locked retinals that are important for applications in the context of optogenetics. The C11-C15 cyclopentyl fragments of both retinals were obtained by palladium-catalysed alkoxycarbonylation and merged with the rest of the carbon skeleton through Wittig olefination. The preparation of the required and known ylide precursor was revisited and optimised. This synthetic route enables gram-scale preparation of both retinal derivatives.
- 出版日期2014-11
