A French national breast and thyroid cancer screening programme for survivors of childhood, adolescent and young adult (CAYA) cancers - DeNaCaPST programme

作者：Demoor Goldschmidt Charlotte; Drui Delphine; Doutriaux Isabelle; Michel Gerard; Auquier Pascal; Dumas Agnses; Berger Claire; Bernier Valerie; Bohrer Sandrine; Bondiau Pierre Yves; Filhon Bruno; Fresneau Brice; Freycon Claire; Stefan Dinu; Helfre Sylvie; Jackson Angela; Kerr Christine; Laprie Anne; Leseur Julie; Mahe Marc Andre; Oudot Caroline; Pluchard Claire; Proust Stephanie; Sudour Bonnange Helene; Vigneron Celine; Lassau Nathalie; Schlumberger Martin

来源：BMC Cancer, 2017, 17(1): 326.

DOI：10.1186/s12885-017-3318-1

• Childhood cancer
• Survivor
• Childhood cancer survivor
• Breast cancer screening
• Thyroid cancer screening
• Breast
• Thyroid
• Second cancer
• Secondary cancer

Background: Survival of childhood, adolescent and young adult (CAYA) cancers has increased with progress in the management of the treatments and has reached more than 80% at 5 years. Nevertheless, these survivors are at great risk of second cancers and non-malignant co-morbidities in later life. DeNaCaPST is a non-interventional study whose aim is to organize a national screening for thyroid cancer and breast cancer in survivors of CAYA cancers. It will study the compliance with international recommendations, with the aim, regarding a breast screening programme, of offering for every woman living in France, at equal risk, an equal screening.
Method: DeNaCaPST trial is coordinated by the INSERM 1018 unit in cooperation with the LEA (French Childhood Cancer Survivor Study for Leukaemia) study's coordinators, the long term follow up committee and the paediatric radiation committee of the SFCE (French Society of Childhood Cancers). A total of 35 centres spread across metropolitan France and la Reunion will participate. FCCSS (French Childhood Cancer Survivor Study), LEA and central registry will be interrogated to identify eligible patients. To participate, centers agreed to perform a complete "long-term follow-up consultations" according to good clinical practice and the guidelines of the SFCE (French Society of Children Cancers).
Discussion: As survival has greatly improved in childhood cancers, detection of therapy-related malignancies has become a priority even if new radiation techniques will lead to better protection for organs at risk. International guidelines have been put in place because of the evidence for increased lifetime risk of breast and thyroid cancer. DeNaCaPST is based on these international recommendations but it is important to recognize that they are based on expert consensus opinion and are supported by neither nonrandomized observational studies nor prospective randomized trials in this specific population. Over-diagnosis is a phenomenon inherent in any screening program and therefore such programs must be evaluated.

• 出版日期2017-5-12