A crude extract from immature green tea (Camellia sinensis) leaves promotes Toll-like receptor 7-mediated interferon-alpha production in human macrophage-like cells

作者：Monobe Manami^*; Ogino Akiko; Ema Kaori; Tokuda Yoshiko; Maeda Yamamoto Mari

来源：Cytotechnology, 2012, 64(2): 145-148.

DOI：10.1007/s10616-011-9412-3

• Green tea
• Crude extract
• Interferon-alpha
• Toll-like receptor 7

Toll-like receptor 7 (TLR7) senses viral single-stranded RNA (ssRNA), induces the production of type I interferons (IFNs), IFN-alpha and -beta, in macrophages such as dendritic cells (DCs), and its immune system protects the host from virus infection. Here, we found that a crude extract from immature green tea leaves (iTPS) containing a macromolecule with ssRNA fragments, induces IFN-alpha production in human macrophage-like cells. In addition IFN-alpha production was inhibited by treatment with TLR7 inhibitors or a phagocytosis inhibitor.

• 出版日期2012-3