Asymmetric synthesis of arylalanines via asymmetric aza-darzens (ADZ) reaction

作者：Maguire NE; McLaren AB; Sweeney JB^*

来源：Synlett, 2003, (12): 1898-1900.

• aziridine
• dpp
• hydrogenolysis
• (R)-amino acid

(R)-3-Arylalanines may be prepared in high enantiomeric purity from N-dpp imines by a four-step reaction sequence involving asymmetric aza-Darzens reaction, dephosphinylation, hydrogenolysis and hydrolysis. The amino acids thus obtained were of >95% enantiomeric purity.

• 出版日期2003-9-29