A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones

作者：Ilieva Eleonora D; Petkova Nevena I; Nikolova Rositca D^*

来源：Molecules, 2012, 17(5): 4936-4949.

DOI：10.3390/molecules17054936

• pyrrolidine-2,5-dione
• pyrrolidine
• 3-substituted coumarins
• 2-oxo-2H-1-benzopyrane
• Michael addition reaction
• rearrangement
• Nef reaction

A newly found reaction for the synthesis of 3,4-disubstituted 1-hydroxy-pyrrolidine-2,5-diones from 3-substituted coumarins and nitromethane has been elaborated. The reaction involved a simple and convenient experimental procedure. The applicability of the rearrangement reaction is determined.

• 出版日期2012-5