A thermosensitive and biodegradable physical gel with chemically crosslinked nanogels as the building block

作者：Yang, Zigang; Ding, Jiandong^*

来源：Macromolecular Rapid Communications, 2008, 29(9): 751-756.

DOI：10.1002/marc.200700872

• biodegradable
• block copolymers
• gelation
• hydrogels
• sol-gel transition

A triblock copolymer, poly(ethylene glycol)-poly(propylene glycol)--poly(ethylene glycol) was end-capped by acryloyl groups using a biodegradable oligolactide as spacer, and such biodegradable amphiphilic macromers could form micelles in water. A nanogel was prepared via polymerizing macromers in a micelle, and a macroscopic physical gelation was found upon heating a concentrated aqueous nanogel suspension. Such a sol-gel transition with a chemically crosslinked nanogel as the building block was thermoreversible. While the hydrogel affords a promising injectable biomaterial; this research reveals new physics of the thermogelling mechanism of amphiphilic block copolymers.

• 出版日期2008-5-2
• 单位复旦大学