Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population

作者：Tsunoka Tomoko; Kishi Taro^*; Kitajima Tsuyoshi; Okochi Tomo; Okumura Takenori; Yamanouchi Yoshio; Kinoshita Yoko; Kawashima Kunihiro; Naitoh Hiroshi; Inada Toshiya; Ujike Hiroshi; Yamada Mitsuhiko; Uchimura Naohisa; Sora Ichiro; Iyo Masaomi; Ozaki Norio; Iwata Nakao

来源：Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2010, 34(4): 639-644.

DOI：10.1016/j.pnpbp.2010.03.002

• Methamphetamine-induced psychosis
• Schizophrenia
• Glutamate metabotropic receptor 2 gene (GRM2)
• Serotonin receptor 2A gene (HTR2A)
• Tagging SNP
• Functional SNP

Background: Abnormalities in glutaminergic neural transmission have been suggested to be involved in the pathogenesis of schizophrenia. A recent study reported that alterations in the 5-HT2A-mGluR2 complex may be involved in neural transmission in the schizophrenic cortex. In addition, methamphetamine-induced psychosis is thought to be similar to schizophrenia. Therefore, we conducted a case-control study with Japanese samples (738 schizophrenia patients, 196 methamphetamine-induced psychosis patients, and 802 controls) to evaluate the association and interaction between GRM2, HTR2A and schizophrenia.
Methods: We selected three 'tagging SNPs' in GRM2, and two biologically functional SNPs in HTR2A (T102C and A1438G), for the association analysis.
Results: We detected a significant association between methamphetamine-induced psychosis and GRM2 in a haplotype-wise analysis, but not HTR2A. We did not detect an association between GRM2 or HTR2A and schizophrenia. In addition, no interactions of GRM2 and HTR2A were found in methamphetamine-induced psychosis or schizophrenia. We did not detect any novel polymorphisms in GRM2 when we performed a mutation search using methamphetamine-induced psychosis samples.
Conclusion: Our results suggested that GRM2 may play a role in the pathophysiology of methamphetamine-induced psychosis but not schizophrenia in the Japanese population. A replication study using larger samples or samples of other populations will be required for conclusive results.

• 出版日期2010-5-30