A Steroid-Type Antioxidant Targeting the Keap1/Nrf2/ARE Signaling Pathway from the Soft Coral Dendronephthya gigantea

作者：Wu, Jianzhang; Xi, Yiyan; Huang, Lili; Li, Ge; Mao, Qiqi; Fang, Chengyan; Shan, Tizhuang; Jiang, Wei; Zhao, Min; He, Wenfei; Dong, Jianyong; Li, Xiubao; Qiu, Peihong^*; Yan, Pengcheng^*

来源：Journal of Natural Products, 2018, 81(11): 2567-2575.

DOI：10.1021/acs.jnatprod.8b00728

• OXIDATIVE STRESS
• EXPRESSION
• MECHANISM
• ESTROGEN
• CELLS

Four new steroids, named 7-dehydroerectasteroid F (1), 11 alpha-acetoxyarmatinol A (2), 22,23-didehydroarmatinol A (3), and 3-O-acetylhyrtiosterol (4), together with 11 previously described analogues, were isolated from a South China Sea collection of the soft coral Dendronephthya gigantea. The structures of the new steroids were elucidated by comprehensive spectroscopic analysis and by comparison with previously reported data. Compound 1 showed potent protection against H2O2-induced oxidative damage in neuron-like PC12 cells by promoting nuclear translocation of Nrf2 and enhancing the expression of HO-1. 1 represents the first steroid-type antioxidant from marine organisms.

• 出版日期2018-11
• 单位海南大学; 温州医科大学; 扬州大学; 宁波市医疗中心李惠利医院