A metal-organic framework with unusual nanocages: Drug delivery

作者：Luo, Zhidong; Wang, Rui; Gu, Chuying; Li, Fumei; Han, Yaoyao; Li, Baohong; Liu, Jianqiang^*

来源：Inorganic Chemistry Communications, 2017, 76: 91-94.

DOI：10.1016/j.inoche.2017.01.002

• Nanocage
• Drug delivery
• Cytotoxicity assay

An unusual nanocage-based framework of [Zn-2(L)(H2O)(1.5)].5H(2)O(1) was used as a drug carrier of 5-fluorouracil (5-FU) for drug delivery. The incorporation of drug 5-FU into the 1 was around 48.6 wt% per gram of dehydrated 1.5-Fllis released in a highly controlled and progressive manner with 98% of the drug release after 101 h at acidic condition and with 62% after 72 hat PBS. 1 did not exhibit any significant cytotoxicity using the vitro cytotoxicity assays. The result from this study suggested a new approach for MOFs to be used as potential drug delivery.

• 出版日期2017-2
• 单位广东医科大学