Differential Dose Response of mTOR Signaling to Oral Administration of Leucine in Skeletal Muscle and Liver of Rats

作者：Yoshizawa Fumiaki^*; Mochizuki Shinji; Sugahara Kunio

来源：Bioscience Biotechnology and Biochemistry, 2013, 77(4): 839-842.

DOI：10.1271/bbb.120737

• leucine
• eukaryotic initiation factor 4E-binding protein 1 (4E-BP1)
• 70-kDa ribosomal protein S6 kinase (S6K1)
• liver
• skeletal muscle

Phosphorylation of eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and 70-kDa ribosomal protein S6 kinase (S6K1) in the rat liver increased in proportion to the amount of leucine administered, ranging from 0.169 to 1.35 g/kg of body weight. In the skeletal muscle, phosphorylation of these factors reached a plateau at 0.675 g/kg of body weight. The sensitivity of mammalian target of rapamycin (mTOR) signaling to leucine in the skeletal muscle appeared to be higher than that in the liver.

• 出版日期2013-4