Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity

作者：Gancarz Amy M; Wang Zi Jun; Schroeder Gabrielle L; Damez Werno Diane; Braunscheidel Kevin M; Mueller Lauren E; Humby Monica S; Caccamise Aaron; Martin Jennifer A; Dietz Karen C; Neve Rachael L; Dietz David M^*

来源：Nature Neuroscience, 2015, 18(7): 959-+.

DOI：10.1038/nn.4036

Activin receptor signaling, including the transcription factor Smad3, was upregulated in the rat nucleus accumbens (NAc) shell following withdrawal from cocaine. Direct genetic and pharmacological manipulations of this pathway bidirectionally altered cocaine seeking while governing morphological plasticity in NAc neurons. Thus, Activin/Smad3 signaling is induced following withdrawal from cocaine, and such regulation may be a key molecular mechanism underlying behavioral and cellular plasticity in the brain following cocaine self-administration.

• 出版日期2015-7
• 单位MIT