Applicator for RF Thermokeratoplasty: Feasibility Study Using Theoretical Modeling and Ex Vivo Experiments

作者：Trujillo Macarena; Ribera Vicente; Quesada Rita; Berjano Enrique^*

来源：Annals of Biomedical Engineering, 2012, 40(5): 1182-1191.

DOI：10.1007/s10439-011-0492-1

• Conductive keratoplasty
• Cornea
• Ex vivo experiments
• Ophthalmology
• Radiofrequency heating
• Theoretical modeling
• Thermokeratoplasty

Radiofrequency (RF) thermokeratoplasty uses RF currents to alter the curvature of the cornea by means of thermal lesions. An RF applicator which combined a microkeratome suction ring and a circular electrode was designed with the aim of creating circular thermal lesions in a predictable, uniform and safe way. An experimental study was conducted on ex vivo porcine eyes. A theoretical model was also designed. The experimental results showed a lesion depth of 34.2 +/- A 11.0% of corneal thickness at a constant voltage of 50 V up to roll-off (1000 a%26quot;broken vertical bar of impedance). With a voltage of 30 V for 30 s the mean depth was 36.8 +/- A 8.1%. The progress of electrical impedance throughout heating and lesion dimensions were used to compare the experimental and theoretical results. Both the impedance evolution and lesion dimensions obtained from the theoretical model showed good agreement with the experimental findings. The findings suggest that the new applicator could be a suitable option for creating uniform circular thermal lesions.

• 出版日期2012-5