Neurotrophin-3-Over-Expressing Mesenchymal Stem Cell Transplantation Improves Functional Recovery and Axonal Outgrowth in a Rat Model of Spinal Cord Injury

作者：Lee Kyung Hee; Oh Jin Soo; Ha Yoon; Lee Bae Hwan; Pennant William A; Yoon Do Heum; Kim Keung Nyun^*

来源：Tissue Engineering and Regenerative Medicine, 2011, 8(5): 477-481.

• spinal cord injury
• human mesenchymal stem cell
• neurotrophin-3
• transplantation

We investigated whether the transplantation of neurotrophin-3 gene transfected mesenchymal stem cells (NT-3-MSC) could promote hind limb functional recovery and axonal outgrowth in a model of spinal cord injury. We found that NT3-MSC transplantation in the contused spinal cord significantly improved hind limb function, axonal outgrowth, and MSC survival, suggesting that gene therapy combined with MSC treatment may represent a useful strategy for treatment of spinal cord injury.

• 出版日期2011-10