MicroRNAs in the Migration of Mesenchymal Stem Cells

作者：He, Lihong; Zhang, Huanxiang^*

来源：Stem Cell Reviews and Reports, 2019, 15(1): 3-12.

DOI：10.1007/s12015-018-9852-7

• Mesenchymal stem cells
• Cell migration
• miRNAs
• Signaling pathway
• Cytokines

Mesenchymal stem cells (MSCs) represent a promising source of cell-based therapies for treatment of a wide variety of injuries and diseases. Their tropism and migration to the damaged sites, which are elicited by cytokines secreted from tissues around pathology, are the prerequisite for tissue repair and regeneration. Better understanding of the elicited-migration of MSCs and discovering conditions that elevate their migration ability, will help to increase their homing to pathologies and improve therapeutic efficacy. It is increasingly recognized that microRNAs are important regulators of cell migration. Here we summarize current understanding of the microRNA-regulated migration of MSCs.

• 出版日期2019-2
• 单位苏州大学