Arkadia-beyond the TGF-beta pathway

作者：Miyazono Kohei^*; Koinuma Daizo

来源：Journal of Biochemistry, 2011, 149(1): 1-3.

DOI：10.1093/jb/mvq133

• TGF-beta
• EGF
• ubiquitin ligase
• AP2 complex
• endocytosis

Arkadia, also known as ring finger 111 (Rnf111), is an E3 ubiquitin ligase that amplifies transforming growth factor (TGF)-beta family signalling through degradation of negative TGF-beta signal regulators, i.e. Smad7, c-Ski and SnoN. Arkadia plays critical roles in early embryonic development through modulation of nodal signalling, as well as progression of tissue fibrosis and cancer through regulation of TGF-beta signalling. Recent findings suggest that, similar to other ubiquitin ligases, including Smurf1 and 2, Arkadia regulates signalling pathways other than those of the TGF-beta family. Arkadia interacts with the clathrin-adaptor 2 (AP2) complex and regulates endocytosis of certain cell surface receptors, leading to modulation of epidermal growth factor (EGF) and possibly other signalling pathways.

• 出版日期2011-1