Association of schizophrenia with T102C (rs6313) and 1438 A/G (rs6311) polymorphisms of HTR2A gene

作者：Yildiz Saliha Handan^*; Akilli Asli; Bagcioglu Erman; Erdogan Mujgan Ozdemir; Coskun Kerem Senol; Alpaslan Ahmet Hamdi; Subasi Burak; Terzi Evrim Suna Arikan

来源：ACTA NEUROPSYCHIATRICA, 2013, 25(6): 342-348.

DOI：10.1017/neu.2013.22

• HTR2A
• polymorphism
• schizophrenia
• T102C
• 1438 A
• G

Objective The aim of this study is to investigate whether there were any associations between the T102C and 1438 A/G polymorphisms of the 5-HT2A receptor gene and schizophrenia. We conducted a case-control study of the T102C and 1438 A/G polymorphisms in Turkish patients.
Methods We compared genotypes and allele frequencies of T102C and 1438 A/G polymorphisms of 5-HT2A receptor gene in 102 patients with schizophrenia diagnosed, according to DSM-IV, and 107 healthy controls. Genotyping was performed by real-time polymerase chain reaction.
Results We found no significant association between schizophrenia and genotypic or allele frequencies of HTR2A gene 102T/C (rs6313) and 1438 A/G (6311) polymorphisms. However, comparison of HTR2A gene 102 T/C and 1438 A/G polymorphisms in terms of genotypic and allele frequencies between the two patient groups, with or without a family history of schizophrenia, shows that T- and A-allele frequencies were significantly higher (p < 0.05) in the case group that has a history of schizophrenia in their family.
Conclusion In conclusion, our results do not support the hypothesis that the T102C and 1438 A/G polymorphisms in the 5-HT2A receptor gene are associated with schizophrenia, but further studies in a larger sample are needed.

• 出版日期2013-12