Association between Plasminogen Activator Inhibitor-1-675 4G/5G Polymorphism and Sepsis: A Meta-Analysis

作者：Li, Li; Nie, Wei; Zhou, Hongfeng; Yuan, Weifeng; Li, Weifeng; Huang, Wenjie^*

来源：PLos One, 2013, 8(1): e54883.

DOI：10.1371/journal.pone.0054883

• DISSEMINATED INTRAVASCULAR COAGULATION
• MENINGOCOCCAL SEPTIC SHOCK
• INTENSIVE-CARE-UNIT
• PROMOTER POLYMORPHISM
• PLASMINOGEN-ACTIVATOR-INHIBITOR-1 GENE
• PAI-1 GENE
• CHILDREN
• INCREASE
• DISEASE
• PROGNOSIS

Background: Several studies have evaluated the association between plasminogen activator inhibitor-1 (PAI-1) -675 4G/5G polymorphism and sepsis in different populations. However, the available results are conflicting.
Methods: A search of Pubmed and EMBASE databases was performed to identify relevant studies for inclusion in the meta-analysis. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were determined using a random-effects model.
Results: Twelve case-control studies and three cohort studies were included. Overall, a significant association between 4G/5G polymorphism and sepsis risk was observed for 4G/4G vs. 4G/5G +5G/5G (OR = 1.30, 95% CI 1.08-1.56, P = 0.006). In addition, there was a significant association between PAI-1 4G/5G polymorphism and sepsis-related mortality (OR = 1.72, 95% CI 1.27-2.33, P = 0.0005). In subgroup analyses, increased sepsis risk and mortality risk were found in Caucasians and in patients with sepsis.
Conclusions: This meta-analysis suggested that the PAI-1 -675 4G/5G polymorphism was a risk factor for sepsis and sepsis mortality.

• 出版日期2013-1-30
• 单位广州军区广州总医院; 天津市中医药研究院附属医院; 中国人民解放军第二军医大学