Diastereoselective synthesis of oxazolo[3,4-b] tetrahydroisoquinolin-3-ones via Lewis acid TMSOTf-mediated Pictet-Spengler reaction

作者：Zhang, Zhenbei; Liu, Tong-Xin^*; Liu, Qingfeng; Zhang, Zhiguo; Zhang, Guisheng

来源：Tetrahedron: Asymmetry , 2013, 24(24): 1591-1597.

DOI：10.1016/j.tetasy.2013.10.015

• BETA-AMINO ALCOHOLS
• ANTITUMOR-ACTIVITY
• PODOPHYLLOTOXIN
• DERIVATIVES
• LIGANDS
• ANALOGS
• KETONES
• REDUCTION
• ALDEHYDES
• EFFICIENT

An alternative and efficient method to stereoselectively synthesize oxazolo[3,4-b]tetrahydroisoquinolin-3-ones via a Pictet-Spengler reaction promoted by Lewis acid TMSOTf from readily available (S)-4-benzyl-2-oxazolidinone with various aromatic, aliphatic, and cyclic aldehydes under room temperature is described.

• 出版日期2013-12-31
• 单位河南师范大学