A cross-sectional serum investigation of a clustering hepatitis C virus infection in Southwest China

作者：Peng, Haoran; Zhang, Longyan; Feng, Yue; Tang, Hailin; Luo, Zhenghan; Qi, Zhongtian; Xia, Xueshan^*; Zhao, Ping^*

来源：Journal of Medical Virology, 2019, 91(3): 508-513.

DOI：10.1002/jmv.25315

• clustering infection
• hepatitis C virus (HCV)
• liver function indexes
• neutralizing antibodies

Serum samples were collected in a village with a clustering hepatitis C virus (HCV) infection. HCV antibody, HCV RNA loads, liver function indexes, HCV envelope antibody, and neutralizing activity were assessed. Among 851 adult sera, 342 samples were positive for anti-HCV. Of these positive samples, 254 (74.3%) were HCV RNA positive (>= 800 copies/mL). None of the 69 children's sera were positive for HCV antibody or RNA. Among the HCV antibody positive sera, alanine aminotransferase, and aspartate aminotransferase levels increased with the higher virus loads, but decreased when virus loads were higher than 1 x 10(6) copies/mL. HCV envelope antibody and neutralizing antibody levels increased with viral load.

• 出版日期2019-3
• 单位昆明理工大学; 中国人民解放军第二军医大学