Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air-puff optical coherence tomography and corneal hysteresis

作者：Maczynska, Ewa; Karnowski, Karol; Szulzycki, Krzysztof; Malinowska, Monika; Dolezyczek, Hubert; Cichanski, Artur; Wojtkowski, Maciej; Kaluzny, Bartlomiej; Grulkowski, Ireneusz^*

来源：Journal of Biophotonics, 2019, 12(2): e201800154.

DOI：10.1002/jbio.201800154

• corneal biomechanics
• corneal hysteresis
• optical coherence tomography
• viscoelasticity

Application of the air-puff swept source optical coherence tomography (SS-OCT) instrument to determine the influence of viscoelasticity on the relation between overall the air-puff force and corneal apex displacement of porcine corneas ex vivo is demonstrated. Simultaneous recording of time-evolution of the tissue displacement and air pulse stimulus allows obtaining valuable information related in part to the mechanical properties of the cornea. A novel approach based on quantitative analysis of the corneal hysteresis of OCT data is presented. The corneal response to the air pulse is assessed for different well-controlled intraocular pressure (IOP) levels and for the progression of cross-linking-induced stiffness of the cornea. Micrometer resolution, fast acquisition and noncontact character of the air-puff SS-OCT measurements have potential to improve the in vivo assessment of mechanical properties of the human corneas.

• 出版日期2019-2