科研之友
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摘要
The asymmetric hydrogenation of aromatic ketones catalyzed by L-proline-modified Ru-PPh3/gamma-Al2O3 was investigated. The effects of reaction conditions on the asymmetric hydrogenation of acetophenone were discussed in detail. The results indicated that natural chiral compound L-proline has a good modification effect on the Ru-PPh3/gamma-Al2O3 catalyst. Under the optimum conditions, the conversion of acetophenone was up to 100%, and the enantioselectivity for the formation of (R)-phenyl ethanol was 59.5%. The synergistic effect between L-proline and KOH was observed. The chiral alcohol products could be easily separated by centrifugation. The catalyst was reused several times without remarkable change of enantioselectivity.
