科研之友
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摘要
Introduction: To further increase diagnosis accuracy of lung cancer and seize the optimal opportunity for treatment, in this paper we conducted in-depth analysis on application value of joint detection of CYFRA21-1, NSE, CEA, CA19-9, CA125 and SCC in diagnosis of lung cancer. Materials and methods: In this research, 1000 patients, who have been clinically diagnosed with lung cancer, were selected into observation group, in which there were 312 patients of small cell carcinoma, 458 with adenocarcinoma, and remaining 330 with squamous carcinoma. In addition, 200 healthy people were selected as research objects in control group. Electrochemistry luminescence method was adopted to test index levels of the two groups, respectively, with test items including CYFRA21-1, NSE, CEA, CA19-9, CA125, SCC. Results: Test results showed the serum indexes of observation group were significantly higher than those of control group. In addition, through comparing 3 different types of lung cancer patients, patients with small cell carcinoma had a significantly higher concentration of serum NSE than those with squamous carcinoma or adenocarcinoma; the concentrations of CA125, CEA, CA19-9 in patients with adenocarcinoma were higher than that of patients with squamous carcinoma or small cell carcinoma; the concentrations of CYFRA21-1 in patients with squamous carcinoma was the highest of the three. Moreover, it finally confirmed 958 lung cancer patients in total by testing 6 serum indexes of all selected patients, with positive rate accounting for 87.09%. Conclusion: As a result, it is of vital significance to test serum indexes such as CYFRA21-1, NSE, CEA, CA19-9, CA125, SCC for suspected lung cancer patients, and the concentrations of different indexes play key roles in confirming type of lung cancer. Finally, it concluded that joint detection of serum markers can further enhance diagnosis efficiency, which should be promoted in clinical practice.
- 出版日期2016
- 单位河南大学
