Association of Fibrinogen with Severity of Stable Coronary Artery Disease in Patients with Type 2 Diabetic Mellitus

作者：Hong, Li-Feng; Li, Xiao-Lin; Luo, Song-Hui; Guo, Yuan-Lin; Zhu, Cheng-Gang; Qing, Ping; Wu, Na-Qiong; Li, Jian-Jun^*

来源：Disease Markers, 2014, 2014: 485687.

DOI：10.1155/2014/485687

• C-REACTIVE PROTEIN
• PLASMA-FIBRINOGEN
• CARDIOVASCULAR-DISEASE
• MYOCARDIAL-INFARCTION
• LEUKOCYTE COUNT
• RISK-FACTOR
• INFLAMMATION
• LEVEL
• POLYMORPHISMS
• MORTALITY

Background. Some studies have suggested a relation of plasma fibrinogen to the severity of coronary artery disease (CAD). However, whether plasma fibrinogen can predict the presence and severity of CAD in patients with diabetes mellitus has not been determined. Methods. A total of consecutive 373 diabetic patients with typical angina pectoris who received coronary angiography were enrolled and classified into three groups by tertiles of Gensini score (GS, low group <8; intermediate group 8 similar to 28; high group >28). The relationship between fibrinogen and GS was evaluated. Results. There were correlations of fibrinogen with hemoglobin A1c, Creactive protein, and GS (r = 0.17,r = 0.52, and r = 0.21, resp.; all P < 0.001). Area under the receivers operating characteristic curve of fibrinogen was 0.62 (95% CI 0.56-0.68, P < 0.001) for predicting a high GS. Multivariate analysis suggested that plasma fibrinogen was an independent predictor of a high GS for diabetic patients (OR = 1.40, 95% CI 1.04-1.88, and P = 0.026) after adjusting for traditional risk factors of CAD. Conclusions. The present data indicated that plasma fibrinogen, a readily measurable systematic inflammatory marker, appeared to be an independent predictor for the severity of CAD in diabetic patients.

• 出版日期2014
• 单位心血管疾病国家重点实验室; 中国医学科学院阜外医院; 中国医学科学院北京协和医院; 北京协和医学院; 武汉大学