Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl) pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl) piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3K alpha and PI3K delta for the treatment of cancers

Barlaam Bernard; Cosulich Sabina; Delouvrie Bebedicte; Ellston Rebecca; Fitzek Martina; Germain Herve; Green Stephen; Hancox Urs; Harris Craig S; Hudson Kevin; Lambert van der Brempt Christine; Lebraud Honorine; Magnien Franoise; Lamorlette Maryannick; Le Griffon Antoine; Morgentin Remy; Ouvry Gilles; Page Ken; Pasquet Georges; Polanska Urszula; Ruston Linette; Saleh Twana; Vautier Michel; Ward Lara

doi:10.1016/j.bmcl.2015.10.002

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Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl) pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl) piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3K alpha and PI3K delta for the treatment of cancers

作者：Barlaam Bernard; Cosulich Sabina; Delouvrie Bebedicte; Ellston Rebecca; Fitzek Martina; Germain Herve; Green Stephen; Hancox Urs; Harris Craig S; Hudson Kevin; Lambert van der Brempt Christine; Lebraud Honorine; Magnien Franoise; Lamorlette Maryannick; Le Griffon Antoine; Morgentin Remy; Ouvry Gilles; Page Ken; Pasquet Georges; Polanska Urszula; Ruston Linette; Saleh Twana; Vautier Michel; Ward Lara

来源：Bioorganic & Medicinal Chemistry Letters, 2015, 25(22): 5155-5162.

DOI：10.1016/j.bmcl.2015.10.002