Amberlyst-15 in organic synthesis

作者：Pal Rammohan^*; Sarkar Taradas; Khasnobis Shampa

来源：ARKIVOC, 2012, 2012(1): 570-609.

DOI：10.3998/ark.5550190.0013.114

• Amberlyst-15
• heterogeneous
• recyclable
• acid catalysis
• organic synthesis

Commercially available Amberlyst-15 has played an important role in organic synthesis. This review summarizes the versatile synthetic applications of Amberlyst-15 in different chemical transformations. Reactions include esterification, transesterification, Michael addition, aza-Michael addition, Prins cyclization, Friedel-Crafts alkylation, acylation, metal free hydroarylation, hydroalkylation, halogenation, protection of carbonyls, amines, deprotection of acetals, acetates, Boc-protected amines, cleavage of epoxides, crossed-aldol condensation, synthesis of quinolines, pyrazolines, indolinones, acridines, calix[4]pyrroles, xanthenes, coumarins, benzopyrans theaspirane, furans, and substituted phosphonates. Applications of this catalyst allow mild and highly selective transformations and synthesis in a facile and environmentally friendly manner. The catalysts can be regenerated and recycled.

• 出版日期2012