Associations between genetic polymorphisms of paraoxonase genes and coronary artery disease in a Taiwanese population

作者：Chen Chi Ching; Chen Chien Chung; Tu Jun Da; Wu Yi Ling; Leu Sy Jye^*

来源：Clinical Biochemistry, 2013, 46(16-17): 1664-1667.

DOI：10.1016/j.clinbiochem.2013.05.066

• CAD
• Gene polymorphisms
• Paraoxonase
• PON1
• PON2

Objective: We evaluated the relationship between polymorphisms of the paraoxonase (PUN) gene and the risk of coronary artery disease (CAD) in Taiwanese patients. %26lt;br%26gt;Methods: Our sample set included 369 volunteers, classified into two groups: 162 healthy volunteers and 207 CAD patients aged 60.0 +/- 9.7 and 64.3 +/- 12.3 years, respectively. Polymorphisms of the PON1 and PON2 genes were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques. %26lt;br%26gt;Results: The results indicate that for the PUN) gene, the homozygous genotype RR was found significantly more often among the CAD group compared with the healthy group (OR = 1.965, 95% Cl = 1.223-3.159, p = 0.005). Furthermore, for the PON2 gene, the homozygous genotype CC was found significantly more often among the CAD group compared with the control group (OR = 2.525, 95% CI = 1.103-5.780, p = 0.026). %26lt;br%26gt;Conclusions: Individuals homozygous for the R allele of the PUN) gene and the C allele of the PON2 gene are more likely to have an increased risk of CAD.

• 出版日期2013-11