Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes

作者：Robert Lidia; Harview Christina; Emerson Ryan; Wang Xiaoyan; Mok Stephen; Homet Blanca; Comin Anduix Begonya; Koya Richard C; Robins Harlan; Tumeh Paul C; Ribas Antoni^*

来源：OncoImmunology, 2014, 3(6): e29244.

DOI：10.4161/onci.29244

• CTLA-4
• MK-3475
• PBMC
• PD-1
• TCR
• Tremelimumab
• sequencing

Targeting immune inhibitory receptors has brought excitement, innovation and hope to cancer patients. Our recent work revealed the immunological effects of blocking the CTLA4 and PD-1 immune checkpoints on T cell receptor usage among peripheral blood cells, and further uncovers how the expansion of the T cell repertoire matches the immunotoxicity profile of the therapy.

• 出版日期2014-6