Association between low-dose aspirin and periodontal disease: results from the continuous national health and nutrition examination survey (NHANES) 2011-2012

作者：Kotsakis Georgios A^*; Thai Ashley; Ioannou Andreas L; Demmer Ryan T; Michalowicz Bryan S

来源：Journal of Clinical Periodontology, 2015, 42(4): 333-341.

DOI：10.1111/jcpe.12380

• aspirin
• epidemiology
• host modulation therapy
• national health and nutrition examination survey
• periodontal diseases
• periodontitis

AimLow-dose aspirin has been hypothesized as being a potential host modulatory agent for periodontitis treatment. We investigated the relationship between low-dose aspirin use and periodontitis prevalence in the continuous National Health and Nutrition Examination Survey, 2011-2012.
MethodsWe analysed n=2335 adult men and women who received a full-mouth periodontal examination and responded to an aspirin use questionnaire. Periodontal disease was defined as severe, moderate or mild according to established case definitions. Mean full-mouth probing depth, attachment loss and tooth loss were also considered. Low-dose aspirin was defined by any self-reported, physician prescribed aspirin use of 162mg/day.
ResultsParticipants had mean age (SE) 55.8years (0.42). The prevalences of periodontitis and low-dose aspirin use were 49.5% and 25% respectively. In multivariable logistic regression models controlling for age, sex, race, socioeconomic variables and comorbidities, the odds ratios [95%CI] for moderate or severe periodontitis among low-dose aspirin users (versus non-users) were: 0.91 [0.56-1.50] and 1.06 [0.74-1.50] respectively. Results were unchanged among participants without diabetes or coronary heart disease.
ConclusionsWithin the limitations of this cross-sectional study we conclude that low-dose aspirin is not associated with prevalent periodontal status in a nationally representative sample of US adults.

• 出版日期2015-4