Autophagy and cell-death proteases in plants - Two wheels of a funeral cart

作者：Bozhkov Peter^*; Jansson Christer

来源：Autophagy, 2007, 3(2): 136-138.

• autophagic programmed cell death
• vacuolar processing enzyme
• metacaspases
• VEIDase
• autophagosomes

Apoptosis is an evolutionarily young cell-death strategy evolved to disassemble animal cells through the action of the caspase family of proteases and phagocytic clearance. This strategy does not work in plants, which instead feature a phylogenetically older autophagic programmed cell death (PCD), as a bona fide type of cellular suicide. Recent work has begun to address the mechanistic roles for autophagic and proteolytic components, as well as their possible cooperation in plant PCD. A recent study has shown outophagosomal localization of a key cell-death proteolytic activity at the early stage of plant PCD. Here we focus on the relationship between autophagic and proteoloytic components in plant PCD at the cellular and organismal levels.

• 出版日期2007-4