An efficient synthesis of chiral cyclic beta-amino acids via asymmetric hydrogenation

作者：Pousset C; Callens R; Marinetti A; Larcheveque M^*

来源：Synlett, 2004, (15): 2766-2770.

DOI：10.1055/s-2004-835659

• beta-aminoacids
• asymmetric synthesis
• rhodium
• ruthenium
• iridium

Cyclic P-amino acids, homoproline, homopipecolic acid and 3-carboxy-methylmorpholine were obtained in high enantiomeric excesses by transition metal-catalyzed asymmetric hydrogenation of cyclic beta-acylamino-alkenoates. These compounds were synthesized by a thio-Wittig reaction on N-protected thiolactames.

• 出版日期2004-12-7