Anticancer Effect of a Novel Octahydropyrazino [2,1-a:5,4-a'] diisoquinoline Derivative and Its Synergistic Action with Nigella sativa in Human Gastric Cancer Cells

作者：Czajkowska Anna; Gornowicz Agnieszka; Pawlowska Natalia; Czarnomysy Robert; Nazaruk Jolanta; Szymanowski Wojciech; Bielawska Anna; Bielawski Krzysztof

来源：Biomed Research International, 2017, 2017: 9153403.

DOI：10.1155/2017/9153403

<jats:p>Many studies have shown that naturally occurring compounds may support prevention and treatment of various diseases, including cancer. Pharmacological investigations revealed a wide spectrum of<jats:italic> Nigella sativa</jats:italic> biological activities. Combining natural compounds together with synthetic drugs may increase the anticancer activity and limit severe side effects of such a treatment and may be an alternative to monotherapy. The aim of the study was to evaluate the cytotoxic and proapoptotic effects of a novel octahydropyrazino[2,1-a:5,4-a′]diisoquinoline derivative and its effect in combination with<jats:italic> Nigella sativa</jats:italic> seed oil or extract in human gastric cancer cells (AGS). Etoposide was used as a reference. Our studies proved that combination strategy based on novel octahydropyrazino[2,1-a:5,4-a′]diisoquinoline derivative (OM-90) with<jats:italic> Nigella sativa </jats:italic>seed oil or extract represents the strongest efficacy in AGS cancer cells as compared to monotherapy and combined treatment with<jats:italic> Nigella sativa </jats:italic>seed oil or extract together with etoposide. Such a combination also leads to the activation of mitochondrial pathway, which plays a significant role in molecular mechanism of induction of apoptosis by these compounds.</jats:p>

• 出版日期2017