Neurobiological aspects of physical activity

作者：Neumann N U^*; Frasch K

来源：Nervenheilkunde, 2009, 28(11): 829-833.

• Activity
• neurobiology
• neurotrophines

Physical activity, especially aerobic endurance training, not only positively influences body weight, the cardiovascular and the musculoskeletal system but has also favourable effects on CNS metabolism. By means of muscular activity neurogenerative, neuroadaptive as well as neuroprotective modes of action are initiated. Animal experimental data suggest that these mechanisms are mediated by neurotrophic factors while favourable effects,have most of all been demonstrated with regard to learning and memory performance. Concerning human beings, there is evidence that physical activity may be of preventive and therapeutic value regarding conditions like obesity, the metabolic syndrome, type 11 diabetes and cardiovascular diseases on the one hand as well as even malignant neoplasms, dementias and depressive syndromes on the other. The exact nature of the underlying metabolic and neural interactions between activated muscles and the CNS are still unknown, as are the mechanisms accounting for autonomic regulation of spontaneous motor activity.

• 出版日期2009