Emerging understanding of dosimetric factors impacting on dysphagia and nutrition following radiotherapy for oropharyngeal cancer

作者：Cartmill Bena^*; Cornwell Petrea; Ward Elizabeth; Davidson Wendy; Nund Rebecca; Bettington Catherine; Rahbari Reza Masoud; Poulsen Michael; Porceddu Sandro

来源：Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 2013, 35(8): 1211-1219.

DOI：10.1002/hed.23040

• radiation dosimetry
• dose-volume histogram
• oropharyngeal cancer
• swallowing
• nutrition
• functional outcomes

BackgroundResearch has reported relationships between 3-dimensional (3D) radiation dose to head and neck structures and consequential swallowing/nutritional outcomes. However, this evidence is preliminary. The current study aimed to identify which reported dose constraints identified functional impairment at 6 months posttreatment. %26lt;br%26gt;MethodsDose constraints with reported relationships to swallowing and nutrition were identified through a systematic literature review. Dose-volume histograms for 12 patients with T1-T3 oropharyngeal cancer treated with 3D conformal radiotherapy determined dosages delivered to specific structures. Doses were examined in relation to published dose constraints and the swallowing and nutritional outcomes at 6 months posttreatment. %26lt;br%26gt;ResultsIn all, 66% of the reported mean, maximum, and partial doses to 8 structures correctly identified swallowing and nutrition outcomes at 6 months. %26lt;br%26gt;ConclusionThe relationships observed between known dosimetric constraints and functional outcomes highlight the potential for dosimetric data to assist in prognosis and treatment. Systematic research is required to refine dosimetric parameters and the impact on functional outcomes.

• 出版日期2013-8