Antibacterial Activity of Pd(II) Complexes with Salicylaldehyde-Amino Acids Schiff Bases Ligands

作者：Rimbu Cristina; Danac Ramona; Pui Aurel^*

来源：CHEMICAL & PHARMACEUTICAL BULLETIN, 2014, 62(1): 12-15.

DOI：10.1248/cpb.c12-01087

• salicylaldehyde-amino acid Schiff base
• Pd(II) complex
• antibacterial activity

Palladium(II) complexes with Schiff bases ligands derived from salicylaldehyde and amino acids (Ala, Gly, Met, Ser, Val) have been synthesized and characterized by Fourier transform (FT)-IR, UV-Vis and H-1-NMR spectroscopy. The electrospray mass spectrometry (ES-MS) spectrometry confirms the formation of palladium(II) complexes in 1/2 (M/L) molar ratio. All the Pd(II) complexes 1, [Pd(SalAla)(2)]Cl-2; 2, [Pd(SalGly)(2)]Cl-2; 3, [Pd(SalMet)(2)]Cl-2; 4, [Pd(SalSer)(2)]Cl-2; 5, [Pd(SalVal)(2)]Cl-2; have shown antibacterial activity against Gram-positive bacteria Staphylococcus aureus and Gram-negative bacteria Escherichia coli.

• 出版日期2014-1