Alcohol and HERZ Polymorphisms as Risk Factor for Cardiotoxicity in Breast Cancer Treated with Trastuzumab

作者：Lemieux Julie^*; Diorio Caroline; Cote Marc Andre; Provencher Louise; Barabe Frederic; Jacob Simon; St Pierre Christine; Demers Eric; Tremblay Lemay Rosemarie; Nadeau Larochelle Corinne; Michaud Annick; Laflamme Christian

来源：Anticancer Research, 2013, 33(6): 2569-2576.

• Alcohol
• HER2 polymorphism
• trastuzumab
• cardiac risk factors

Background: Trastuzumab has no major side-effects except the potential for cardiac toxicity. The main objective of this study was to evaluate the association between trastuzumab-associated cardiac toxicity and two potential risk factors: alcohol intake and HER2 polymorphisms. Patients and Methods: In a retrospective cohort study of 237 women with non-metastatic HER2-positive breast cancer treated with trastuzumab, traditional risk factors were assessed by review of medical records, alcohol use by an administered questionnaire to women (n=132), and HER2 polymorphisms (Ile655Val and Ala1170Pro) using TaqMan assays (n=73). Results: Association was observed between alcohol intake (10 drinks and more per week) during the trastuzumab treatment and cardiac toxicity (p=0.04). For polymorphisms, compared to Ile/Ile carriers, HER2 Ile/Val was associated with a higher risk of cardiac toxicity (p=0.02). Conclusion: Heavy alcohol use during the course of trastuzumab treatment and the HER2 Ile/Val genotype may constitute risk factors for cardiac toxicity.

• 出版日期2013-6