A bimetallic aluminium(salen) complex for asymmetric cyanohydrin synthesis

作者：North Michael^*; Williamson Courtney

来源：Tetrahedron Letters, 2009, 50(26): 3249-3252.

DOI：10.1016/j.tetlet.2009.02.028

In the presence of a phosphine oxide cocatalyst, a bimetallic aluminium(salen) complex was found to catalyse the asymmetric addition of trimethylsilyl cyanide to aldehydes. Under optimised conditions, enantioselectivities of 53-96% were obtained using 2 mol% of the catalyst. An analysis of the reaction kinetics showed that the reactions exhibited first-order kinetics, with the race of reaction being independent of the aldehyde concentration.

• 出版日期2009-7-1