A synthesized butyrolactone derivative in combination with chloroquine can inhibit cancer cell growth and lysosome vacuolation induced by chloroquine in A549 lung cancer cells

作者：Chen, Xin-Peng; Fan, Chuan-Dong; Su, Le; Zhao, Bao-Xiang^*; Miao, Jun-Ying^*

来源：RSC Advances, 2016, 6(59): 54099-54101.

DOI：10.1039/c6ra02533a

• VASCULAR ENDOTHELIAL-CELLS
• COMPETING ENDOGENOUS RNA
• MESSENGER-RNAS
• IN-VITRO
• AUTOPHAGY
• PROLIFERATION
• NA+,K+-ATPASE
• ACIDIFICATION
• METABOLISM
• APOPTOSIS

3BDO in combination with chloroquine could elevate the Na+, K+-ATPase activity and decrease the expression of long non-coding RNA TGFB2-OT1. Therefore, the combination inhibited the cell growth and lysosomal vacuolation.

• 出版日期2016
• 单位山东大学