Gonadotropin-controlled mammal oocyte meiotic resumption

作者：Zhang Meijia; Xia Guoliang^*; Zhou Bo; Wang Chao

来源：Frontiers in Bioscience, 2007, 12: 282-296.

DOI：10.2741/2064

• gamete biology
• meiotic resumption
• kinases
• signal transduction
• review

Fully grown mammalian oocytes resume meiosis as a consequence of rises in gonadotropin levels at the midcycle. The increase of cyclic adenosine 3', 5'monophosphate ( cAMP) and the activation of protein kinase A ( PKA), protein kinase C ( PKC) and mitogenactivated protein kinase ( MAPK) in cumulus cells are required for gonadotropins- induced meiotic resumption of oocytes. The various actions of cAMP activated by folliclestimulating hormone ( FSH) and luteinizing hormone ( LH) also include meiosis activating sterol ( MAS), gonadal steroid hormones and epidermal growth factor ( EGF) network during meiotic resumption. Another second messenger guanosine 3', 5'- cyclic monophosphate ( cGMP) induced by nitric oxide ( NO) or atrial natriuretic peptide ( ANP) also mediates gonadotropins- controlled mammalian oocyte meiotic resumption. The different actions of FSH and LH on meiotic resumption are discussed. We hope to provide a framework to understand how the initial signals generated by gonadotropins- stimulation control the expression of genes required for meiotic resumption.

• 出版日期2007-1-1
• 单位中国农业大学