科研之友
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摘要
A novel bioinspired phospholipid copolymer was synthesized by the free radical polymerization of poly-2-methacryloyloxyethylphosphorylcholine (MPC), stearyl methacrylate (SMA), hydroxypropyl methacrylate(HPMA) and trimethoxysilylpropyl methacrylate(TSMA). A stable cross-linked coating was obtained via dip-coating, followed by curing at 70 degreesC for 9 h. Contact angle results indicate the coating surface rearrange to get a more hydrophilic surface on the polymer/water interface. The membrane mimic phosphorylcholine coating surface can resist the platelet adhesion and prolong plasma recalcification time significantly. Rhodamine S was used as model drugs to prepare drug-containing coating under the same conditions. Drug-releasing curves fall into Fickian release mechanism and there exists an efficient releasing amount of the drug until 60 h.
- 出版日期2004-1
- 单位浙江大学
