Antiplasmodial decarboxyportentol acetate and 3,4-dehydrotheaspirone from Laumoniera bruceadelpha

作者：Morita Hiroshi^*; Mori Reika; Deguchi Jun; Oshimi Shiori; Hirasawa Yusuke; Ekasari Wiwied; Widyawaruyanti Aty; Hadi A Hamid A

来源：Journal of Natural Medicines, 2012, 66(3): 571-575.

DOI：10.1007/s11418-011-0618-7

• Decarboxyportentol acetate
• 3,4-Dehydrotheaspirone
• Laumoniera bruceadelpha
• Simaroubaceae
• Antiplasmodial activity
• Plasmodium falciparum 3D7

A new spiro heterocycle, decarboxyportentol acetate (1) was isolated from the barks of Laumoniera bruceadelpha Nooteboom (Simaroubaceae), together with 3,4-dehydrotheaspirone (2), and their structures were elucidated by 2D NMR analysis. 3,4-Dehydrotheaspirone (2) showed potent antiplasmodial activity against Plasmodium falciparum 3D7.

• 出版日期2012-7