An Evidence-Based Meta-Analysis on the Roles of Functional Interleukin-6 Polymorphisms in Coronary Artery Disease

作者：Zhang, Haixia; Liu, Cuiyi; Zhao, Boming; Zhou, Xiaodong^*

来源：Journal of Interferon and Cytokine Research, 2018, 38(9): 370-377.

DOI：10.1089/jir.2018.0075

• interleukin-6 (IL-6)
• genetic polymorphisms
• coronary artery disease
• meta-analysis

Recently, the relationship between functional interleukin-6 (IL-6) polymorphisms and coronary artery disease (CAD) was extensively studied, with controversial findings. Therefore, we conducted this meta-analysis to better elucidate the relationship between these polymorphisms and the risk of CAD. A total of 57 case-control studies were finally included. The overall analyses showed that IL-6 -174G>C and -572G>C polymorphisms were significantly associated with the risk of CAD, the C allele of -174G>C (G versus C, odds ratio [OR]=0.82, confidence interval [95% CI]=0.75-0.89) and -572G>C polymorphisms (G versus C, OR=0.82, 95% CI=0.74-0.92) conferred an increased susceptibility to CAD. Further subgroup analyses yielded similar positive results for -174G>C polymorphism in Asian and Caucasian populations, and for -572G>C polymorphism in Asian and African populations. In conclusion, our findings suggest that IL-6 -174G>C and -572G>C polymorphisms may serve as potential genetic markers of CAD.

• 出版日期2018-9
• 单位南昌大学