Antidepressant-like effects of mild hypoxia preconditioning in the learned helplessness model in rats

作者：Rybnikova Elena^*; Mironova Vera; Pivina Svetlana; Tulkova Ekaterina; Ordyan Natalia; Vataeva Ludmila; Vershinina Elena; Abritalin Eugeny; Kolchev Alexandr; Nalivaeva Natalia; Turner Anthony J; Samoilov Michail

来源：Neuroscience Letters, 2007, 417(3): 234-239.

DOI：10.1016/j.neulet.2007.02.048

• depression
• learned helplessness model
• hypoxic preconditioning
• hypoxic/ischemic tolerance

The effects of preconditioning using mild repetitive hypobaric hypoxia (360 Torr for 2 h each of 3 days) have been studied in the learned helplessness model of depression in rats. Male Wistar rats displayed persistent depressive symptoms (depressive-like behaviour in open field, increased anxiety levels in elevated plus maze, ahedonia, elevated plasma glucocorticoids and impaired dexamethasone test) following the exposure to unpredictable and inescapable footshock in the learned helplessness paradigm. Antidepressant treatment (ludiomil, 5 mg/kg i.p.) augmented the development of the depressive state. The hypoxic preconditioning had a clear antidepressive action returning the behavioural and hormonal parameters to the control values and was equally effective in terms of our study as the antidepressant. The findings suggest hypoxic preconditioning as an effective tool for the prophylaxis of post-stress affective pathologies in humans.

• 出版日期2007-5-7
• 单位中国人民解放军军事医学科学院