A novel design of a polynuclear co-delivery system for safe and efficient cancer therapy

作者:Xing, Lei; Zhang, Jia-Liang; Zhou, Tian-Jiao; He, Yu-Jing; Cui, Peng-Fei; Gong, Jia-Hui; Sun, Minjie; Lu, Jin-Jian; Huang, Zhangjian; Jin, Liang*; Jiang, Hu-Lin*
来源:Chemical Communications, 2018, 54(63): 8737-8740.
DOI:10.1039/c8cc03720e

摘要

We report a novel and easy-to-fabricate polynuclear nanoparticle based on the collaborative re-assembly of nanoparticles as a robust chemogene co-delivery platform. Specifically, the polynuclear nanoparticle carrying DOX and siBcl-2 exerts remarkable co-delivery efficiency, increases tumour cell apoptosis and inhibits tumour cell proliferation in vitro and in vivo.

  • 出版日期2018-8-14
  • 单位中国药科大学; 中国人民解放军南京军区福州总医院; 天然药物活性组分与药效国家重点实验室; 澳门大学; 厦门大学