Antibacterial and anti-adhesion effects of the silver nanoparticles-loaded poly(L-lactide) fibrous membrane

作者：Liu, Shen; Zhao, Jingwen; Ruan, Hongjiang; Wang, Wei; Wu, Tianyi; Cui, Wenguo; Fan, Cunyi^*

来源：Materials Science & Engineering C-Materials for Biological Applications, 2013, 33(3): 1176-1182.

DOI：10.1016/j.msec.2012.12.008

• Peritendinous adhesions
• Infection
• Bacteria
• Electrospun fibrous membrane
• Silver nanoparticle

The complications of tendon injury are frequently compromised by peritendinous adhesions and tendon sheath infection. Physical barriers for anti-adhesion may increase the incidence of postoperative infection. This study was designed to evaluate the potential of silver nanoparticles (AgNPs)-loaded poly(L-lactide) (PLLA) electrospun fibrous membranes to prevent adhesion formation and infection. Results of an in vitro drug release study showed that a burst release was followed by sustained release from electrospun fibrous membranes with a high initial silver content. Fewer fibroblasts adhered to and proliferated on the AgNP-loaded PLEA electrospun fibrous membranes compared with pure PLEA electrospun fibrous membrane. In the antibacterial test, the AgNP-loaded PLEA electrospun fibrous membranes can prevent the adhesion of Gram-positive Staphylococcus aureus and Staphylococcus epidermidis and Gram-negative Pseudomonas aeruginosa. Taken together, these results demonstrate that AgNP-loaded PLLA electrospun fibrous membranes have the convenient practical medical potential of reduction of infection and adhesion formation after tendon injury.

• 出版日期2013-4-1
• 单位苏州大学; 南京医科大学; 上海交通大学