Apolipoprotein H: Its relevance to cardiovascular disease

作者：Crook M A^*

来源：Atherosclerosis, 2010, 209(1): 32-34.

DOI：10.1016/j.atherosclerosis.2009.11.022

• Apo H
• Diabetes mellitus
• Lipids
• Antiphospholipid antibody syndrome
• Cardiovascular disease
• beta2-Glycoprotein I

Apolipoprotein H (Apo H) is a single chain glycoprotein consisting of 326 amino acid residues with a molecular weight of about 50 kDa and is involved in clotting mechanisms and lipid pathways [1]. Castro and colleagues report in this journal that plasma concentrations of Apo H are strongly associated with the metabolic syndrome and cardiovascular disease in type 2 diabetic patients and could be considered as a clinical marker of cardiovascular risk. The increased Apo H concentration in these patients was due to its increased liver synthesis. Apo H is attracting interest in the field of cardiovascular disease, diabetes mellitus, haemostasis and lipidology and may provide an exciting link between them but why is this?

• 出版日期2010-3