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摘要
The desymmetrisation of prochiral alpha, alpha-dicyanoalkenes via tandem Michael-Michael addition reactions with alpha, beta-unsaturated ketones catalysed by 9-amino-9-deoxyepicinchona alkaloids was investigated, from which bicyclic products bearing four stereogenic centers were afforded in a single operation with high stereoselectivities (> 99% de, up to > 99.5% ee).
- 出版日期2008
- 单位四川大学
