New amino butenolides from the bulbs of Fritillaria unibracteata

作者：Liu, Juan; Peng, Cheng^*; He, Cheng-Jun; Liu, Jian-Lin; He, Ya-Cong; Guo, Li; Zhou, Qin-Mei; Yang, Huai; Xiong, Liang

来源：Fitoterapia, 2014, 98: 53-58.

DOI：10.1016/j.fitote.2014.07.009

• Fritillaria unibracteata
• Liliaceae
• Amino butenolides
• Amide alkaloids

Five new amino gamma-butenolides, fritenolide A (1), B (2), C (3), D (4), and E (5), along with four known compounds, were isolated from the bulbs of Fritillaria unibracteata. Their structures were determined by spectroscopic analysis, including 1D NMR, 2D NMR, HRESIMS, HRESIMS/MS, IR, and CD techniques. All isolates were evaluated for the protective activity on injured hepatocytes and cytotoxic activity on human cancer cells in vitro. The unusual amino butenolides were isolated from the Liliaceae family for the first time.

• 出版日期2014-10
• 单位成都中医药大学